PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1131-1141

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EFFECT OF TRIPHALA- AN AYURVEDIC HERBAL FORMULATION ON DOXORUBICIN INDUCED CARDIO TOXICITY IN RATS

Author: MITRA M, SHIVALINGEGOWDA KP*

Category: Pharmaceutical Sciences

Abstract:

The objective was to evaluate the cardioprotective activity of triphala in doxorubicin induced cardiotoxicity in albino wistar rats. Twenty- four rats were divided into four groups (n=6). Group I (normal) received normal saline (p.o.) for 10 days. The group II rats received doxorubicin HCl (15mg/kg, i.p.) on 7th day. The rats in group III and IV were pretreated with triphala (500mg/kg, p.o. and 1000 mg/kg, p.o.) followed by doxorubicin on 7thday. On 11th day, ECG studies, serum creatinine phosphokinase (CPK), CK-MB and lactate dehydrogenase (LDH) levels as well as anti-oxidant parameters like superoxide dismutase, catalase and lipid peroxidation along with histopathological changes were studied. The doxorubicin treated rats have shown abnormal ECG values along with elevated (*** P <0.001) serum creatinine phosphokinase (CPK), CK-MB, LDH as well as lipid peroxidation levels while significantly reduced values (*** P <0.001 ) of SOD and catalase were observed as compared to group I rats. The triphala and doxorubicin treated rats have shown significant alterations when compared to the doxorubicin alone treated rats suggesting the cardio protection. Histological observations of rat hearts further correlated the cardioprotective effect of triphala. The result of this study provides the experimental evidence for triphala’s cardioprotective effects.

Keywords: Triphala, cardiotoxicity, catalase, lactate dehydragenase, electrocardiogram