PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1142-1151

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ANTI ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACT OF CISSUS QUADRANGULARIS STEM

Author: SUDARSINI SARAVANABHAVAN*, FAHAD I. AL-SAIKHAN

Category: Pharmaceutical Sciences

Abstract:

The hydroalcoholic extract of Cissus quadrangularis stem was investigated to evaluate its anti-ulcer activity by using aspirin induced gastric ulcer model, since non-steroidal anti-inflammatory drugs such as aspirin causes gastrointestinal damages as one of their side effects in human. The hydroalcoholic extract of Cissus quadrangularis stem was administered at the dose of 1000 mg/Kg.b.w to the groups of wistar rat orally for 7 consecutive days, after which gastric ulcer was induced by aspirin. Gross pathological examination reveals that Cissus quadrangularis promotes ulcer protection by decreasing the ulcer index which is evident in the Histopathological observation and qualitative analysis of C-reactive protein

Keywords: Cissus quadrangularis, Anti-ulcer, Histopathology, Hydroalcohol