PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1245-1257

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FORMULATION AND EVALUATION OF PROPRANOLOL HCl EXTENDED RELEASE PELLETS

Author: RAMYASRI ALAPATI*, BHANU PRASAD M, Dr.V.UMAMAHESHWAR RAO, R.SHIREESH KIRAN

Category: Pharmaceutical Sciences

Abstract:

The present study performed by Formulation and Evaluation of Extended Release Pellets of Propranolol HCl which is an anti-hypertensive drug. Pellets were formulated with various materials like ethyl cellulose 7cps, HPMC E-5, HPMC phthalate 55 as rate controlling polymers, Diethyl phthalate as plasticizer, povidone K-30 as binder and Acetone, Isopropyl alcohol as solvents. The pellets were prepared by both Pan coating and fluid bed coating technology. The variant proportion of the polymers ethyl cellulose 7cps, HPMC E-5 and HPMC pthalate 55 showed significant difference in the release rates. The drug release rate decreased as the concentration of ethyl cellulose is increased.

Keywords: Propranolol HCl, Extended release pellets, antihypertensive, fluid bed coating