PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1258-1277

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FORMULATION AND EVALUATION OF BILAYER TABLETS OF SITAGLIPTIN PHOSPHATE AND METFORMIN HYDROCHLORIDE

Author: SAI SUPRAJA.B*, AJAY KUMAR.B, Dr.V.UMAMAHESHWAR RAO, SWARUPA ARVAPALLY

Category: Pharmaceutical Sciences

Abstract:

The purpose of this research work is to establish Metformin Hydrochloride (500mg) as sustained release layer and Sitagliptin Phosphate (50mg) as immediate release layer in the form of bilayer tablets. Sustained release layer is prepared by direct compression method using combination of different polymers like Sodium alginate, HPMC K4M, Carbomer, and Xanthum gum. Immediate release layer is prepared by Wet granulation method by using combination of Superdisintegrants like Crosspovidone, Crosscarmellose intragranularly and extragranularly. Finally both the layers were compressed by direct compression. Tablets were evaluated for different parameters like friability, weight variation, hardness, drug content, dissolution studies, stability studies, ft-ir studies for compatability purpose. The release of one drug remain unaffected in presence of other drug. The optimized formulation gave an Immediate release effect followed by Sustained release effect. The release pattern of Metformin Hydrochloride was fitted to different models based on coefficient of correlation. The present study concluded that bilayer tablets can effectively be formulated to deliver more than one drug so as to have improved patience compliance and better disease management.

Keywords: Metformin Hydrochloride, Sitagliptin Phosphate, UV Visisble spectrophotometer.