PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1278-1283

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A FACTORIAL STUDY ON ENHANCEMENT OF DISSOLUTION RATE OF PIROXICAM BY SOLID DISPERSION TECHNIQUE EMPLOYING STARCH CITRATE, PVP K-30 AND PEG 4000

Author: VEERAIAH ENTURI*, BOYAPATI MRUDULA, K.P.R. CHOWDARY, DEBASISH SWAIN

Category: Pharmaceutical Sciences

Abstract:

Solid dispersion is a widely accepted technique for enhancing the dissolution rate of poorly soluble BCS class II drugs. In the present study starch citrate- a new modified starch, PVP and PEG 4000 were evaluated as a carriers in solid dispersions for enhancing the dissolution rate and efficiency of piroxicam, a BCS class II drug. Their individual and combined (interaction) effects in enhancing the dissolution rate and dissolution efficiency of piroxicam were evaluated in a 23- factorial study. Among the individual effects starch citrate gave highest enhancement in the dissolution rate of piroxicam (11.71 fold), followed by PVP (6.03 fold). Addition of PVP and PEG 4000 to the solid dispersions in starch citrate has further enhanced the dissolution rate upto 66.40 fold and dissolution efficiency upto 13.38 fold.

Keywords: Solid dispersions, Piroxicam, Starch Citrate, PVP K-30, PEG 4000, Factorial Study