PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1340-1349

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SOLUBILITY ENHANCEMENT OF LAMOTRIGINE USING SOLID SELF EMULSIFIED DRUG DELIVERY SYSTEMS

Author: G.SUSHMA*, K.UJJAINI, KALYAN RAJ, RAJYA LAXMI, VINAY UMESH RAO, M.SUDHAKAR

Category: Pharmaceutical Sciences

Abstract:

Lamotrigine is a novel anti epileptic drug which belongs to BCS Class II. Its poor aqueous solubility limits its oral bioavailability. The aim of the current work was to utilize the self emulsifying drug delivery platform to enhance the dissolution of Lamotrigine and thereby improve its oral bioavailability. The composition of the oil phase and the surfactant and co surfactant mixture (S-mix) was optimized by varying the HLB value of the S mix from low of 6 to a high of 14. The stability of the emulsion was determined by physical observation. The drug loaded s-mix was adsorbed on to a solid carrier and the resultant powder was subjected to in vitro dissolution testing in water and in the compendia media. The results were compared to those of plain drug from equivalent mixture.

Keywords: Lamotrigine, BCS class II, oil phase, s-mix, HLB