PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1383-1391

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SYNTHESIS AND ANTIBACTERIAL EVALUATION OF SOME N-(P-SUBSTITUTED BENZYLIDENE)-5-PROPYL-1, 3, 4-THIADIAZOLE-2-AMINES

Author: SUNIL KUMAR*, S. K. SHARMA, SANDEEP JAIN, NEELAM JAIN

Category: Pharmaceutical Sciences

Abstract:

A series of Schiff’s bases i.e., N-(p-substituted benzylidene)-5-propyl-1, 3, 4-thiadiazole-2-amines were synthesized from 2-amino-5-propyl-1, 3, 4-thiadiazole 1 and evaluated for their in vitro antibacterial activity. Reaction of thiosemicarbazide with butanoic acid in presence of concentrated sulfuric acid furnished the compound 1 which on further reaction with different p-substituted benzaldehydes yielded the Schiff’s bases 2. These compounds were characterized by spectral analysis. All the synthesized compounds were screened for their in vitro for their antibacterial activity against two Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative bacterial strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined.

Keywords: 1, 3, 4-Thiadiazole, Schiff’s base, antibacterial, minimum inhibitory concentration (MIC).