PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1392-1400

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A STUDY ON THE EFFECT OF GREEN TEA EXTRACT ON THE LIPID PROFILE OF POST MYOCARDIAL INFARCTION PATIENTS ON HYPOLIPIDAEMIC AND ANTIPLATELET THERAPY

Author: JOSEPH STALIN D*

Category: Pharmaceutical Sciences

Abstract:

This open randomized controlled trial was conducted on post MI patients receiving hypolipidaemic and antiplatelet therapy to assess the effect of Green Tea Extract on their lipid profiles. The 102 patients who were enrolled for the study were divided in to two groups at random and categorized as Group 1 and Group 2. Their baseline serum lipid profiles were measured and documented on the patient data sheet. Then Group 1 was given atorvastatin 40 mg/day and clopidogrel 75 mg/day as they were already taking that along with drugs for diabetes and/or hypertension. Group 2 patients additionally received Green Tea Extract 75 mg/day orally. Both the groups of patients were monitored for compliance, and for ADRs and side effects. At the end of 6 months the lipid profiles of Group 1 were measured and compared with those of Group 2. The results showed that the reduction in serum total cholesterol, and LDL, were much higher in Group 2, compared to Group 1. There were no significant changes in triglyceride, HDL, and VLDL levels in both the groups. The study gives a strong evidence for the lipid lowering action of Green Tea Extract.

Keywords: Green Tea Extract, Cholesterol, Atorvastatin, LDL, Lipid profile