PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1401-1408

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ANALGESIC ACTIVITY OF LEAVES, FLOWERS AND FRUIT PEEL OF LUFFA CYLINDRICA (L.) ROEM

Author: KANWAL WASEEM KHAN, SYED WASEEMUDDIN AHMED, SALMAN AHMED*

Category: Pharmaceutical Sciences

Abstract:

Ethanol extracts of leaves, male flowers and fruit peel of Luffa cylindrica (L.) Roem., were evaluated for analgesic effect using analgesy meter test, a mechanically induced pain model. Extracts at the dose of 500 mg/kg, p.o., were tested and compared with diclofenac sodium 50mg/kg as standard analgesic drug. Mechanical force was applied on the rat paw and continuously increased. The point at which rat can’t bear further pressure and starts struggle to free paw was taken as nociceptive response. Readings were taken before and after 1, 2 and 3hr following drug administration. Analgesic response was continuously increasing till 3hrs. Tested extracts produced significant and comparable analgesic effect as with diclofenac sodium.

Keywords: Luffa cylindrica, analgesic activity, analgesy meter test, mechanically induced pain