PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1409-1418

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GENOME ANALYSIS AND ANNOTATION OF PKC GENE IN BIPOLAR DISORDER

Author: S. SHANTHIPRIYA*, VA DOSS

Category: Pharmaceutical Sciences

Abstract:

Bipolar disorder (BPD) is a complex genetic disorder in which the core feature is pathological disturbance in mood ranging from extreme elation, or mania, to severe depression usually accompanied by disturbances in thinking and behavior. Recent evidence indicates that an alteration in PKC activity plays a significant role in pathophysiology of BPD. Protein kinase C (PKC) is a group of calcium and phospholipid – dependent enzymes, enriched in brain, where it plays a major role in regulating both pre-and postsynaptic aspects of neurotransmission. Inhibition of PKC plays an important role in neuroprotection against BPD. In this paper we have carried out the Gene location in chromosome, Analysis and Annotation. Coding and non-coding region was also identified to predict the Exon in the gene sequence. By using various Bioinformatics tools, the downstream genes were also identified. This analysis may help in further comparative analysis of genes in various organisms and to design a definite drug which inhibits the activity of the gene in Bipolar disorder

Keywords: PKC gene, Bipolar disorder, Genome Analysis.