PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1492-1510

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FORMULATION AND EVALUATION OF PULSATILE COLON SPECIFIC HYDROGEL BEADS OF TERBUTALINE SULFATE FOR NOCTURNAL ASTHMA

Author: PADALA SHRUTI*, BOTLA SIRISHA, Dr.V.UMAMAHESHWAR RAO, P.RAJ KUMAR

Category: Pharmaceutical Sciences

Abstract:

The purpose of this research was to design and evaluate an oral, pulsutile, colon specific multiparticulate device (hydrogel beads) to achieve time and/or site specific release of Terbutaline Sulfate based on chronopharmaceutical approach. Terbutaline Sulfate is short acting beta-adrenergic agonists which are used only for symptomatic relief of asthma. Nocturnal asthma needs chronotherapeutic approach and Terbutaline Sulfate has short half life with a bioavailability of 30-50% orally. In order to provide a oral colon specific action after predetermined lag time this was chosen as the model drug. Hydrogel beads containing Terbutaline sulfate were prepared by ionotropic gelation technique. Various polymers like sodium alginate, celkol, PVA, metalose SR and chitosan were used in different concentrations and combination in the preparation of hydrogel beads. All the formulations were evaluated for surface morphology, particle size analysis, drug content, entrapment efficiency, swelling index , in vitro drug release was carried out in 1.2 pH buffer, 6.8 pH buffer and 7.4 pH buffer for 2 hours,3 hours and 3 hours respectively to mimic the conditions in GIT. It is concluded that hydrogel beads are the potential system for oral pulsatile colon specific delivery of Terbutaline Sulfate for chronotherapy of nocturnal asthma.

Keywords: Pulsatile, colon specific, nocturnal asthma, Terbutaline Sulfate.