PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1511-1524

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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF CARVEDILOL PHOSPHATE

Author: CH. SWATHI KUMARI*, G. SAILAJA, D. PAVITHRA

Category: Pharmaceutical Sciences

Abstract:

The objective of the present research work was to develop sustained release matrix tablets of Carvedilol phosphate (40 mg) using Sodium Carboxy Methyl Cellulose polymer in different ratios, to reduce the dosing frequency. The drug polymer interaction was investigated by FTIR and their results directed further course of formulation. The tablets were prepared by employing direct compression method and were evaluated for various pre compression parameters and post compression studies like weight variation, hardness, friability, thickness, disintegration, drug content and in vitro dissolution studies. In vitro dissolution studies were performed using USP apparatus II (paddle) over a period of 24 hours in 0.1N HCl. The release kinetics was analyzed as per Zero-order, First-order, Higuchi and Peppas equations. The invitro dissolution studies of optimized formulation (F3) showed percentage drug release of about 92.45 % up to 24hrs and showed First-order release kinetics with Fickian diffusion model. The optimized formulation F3 showed similar drug release when compared with innovator (COREG). The result of stability studies (40±2oC/75±5% RH), showed no change in physical properties and in vitro dissolution profile of F3. As per release profile, a decrease in release rate was observed with increase in the viscosity of polymer.

Keywords: Carvedilol phosphate, Sustained release, Sodium Carboxy Methyl Cellulose, COREG.