PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1525-1538

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FORMULATION AND EVALUATION OF TRIHEXYPHENIDYL HYDROCHLORIDE IMMEDIATE RELEASE TABLETS

Author: SURAJ PRAKASH. H*, P. VISHNU, V.UMAMAHESWARA RAO

Category: Pharmaceutical Sciences

Abstract:

The main objective of this research work was to formulate and evaluate the immediate release tablets of Trihexyphenidyl HCL 5mg, an M1 muscarinic acetylcholine receptor antagonist. It blocks cholinergic activity in CNS, which is responsible for the symptoms of Parkinson's disease. The tablets are prepared by direct compression method and wet granulation method. The formulations was optimized by incorporating varying composition of sodium starch glycollate and pregelatinised starch as super disintegrant, lactose and microcrystalline cellulose as diluent, povidone K-30 as binder and magnesium stearate agent as lubricant. All the excipients are tested for compatibility with drug, which revealed that there was no physical and chemical interaction occurred. The Preformulation parameters such as bulk density, tapped density, compressibility index and Hausner ratio were analyzed. The thickness, hardness, friability, weight variation, disintegration time and drug content uniformity was evaluated for core tablets. The effect of these variables on drug release also studied. The In-vitro drug release studied was performed in the USP dissolution apparatus-II (paddle) using pH 4.5 acetate buffer as dissolution media at 100rpm. The cumulative amount of drug release at different intervals is estimated using HPLC method. Based on the evaluation result the formulations F-8 containing MCC and SSG (6%) showed 98.5% release in 30 mins and so it was optimized as best formulation.

Keywords: Trihexyphenidyl, Immediate release, Super disintegrants, Wet granulation, Parkinson’disease.