PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1687-1697

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FORMULATION AND EVALUATION OF FLOATING TABLETS OF FAMOTIDINE

Author: S. RAVINDER REDDY*, P. VISHNU, V.UMAMAHESWARA RAO, SURAJ PRAKASH.H, K.B.V.YASASWI

Category: Pharmaceutical Sciences

Abstract:

The objective of the present investigation is to formulate floating tablets of Famotidine. A histamine H2 receptor antagonist widely prescribed in ulcers like duodenal and gastric Ulcer. The short biological half-life (2.5 - 4 hours) and maximum absorption in initial part of small intestine, colonic metabolism of Famotidine favors’ development of gastro retentive floating dosage form. In the present study Famotidine floating tablets were prepared by effervescence method using sodium bicarbonate as a gas generating agent. The tablets were formulated using direct compression technology by employing polymers like HPMC K4M, HPMC K15M, HPCM K 100M and carbopol 934p. The drug-excipient compatible studies were performed by FTIR, The FTIR study revealed that there is no drug-excipient interaction. The prepared floating tablets were evaluated for various physicochemical parameters such as flow properties, hardness, weight variation, friability, in vitro buoyancy (floating lag time, total floating time), swelling studies, drug content and in-vitro drug release. The in vitro drug release pattern of Famotidine floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with higuchi mechanism. Out of all formulations the one prepared with carbopol 934p and HPMC K100Mcombination was optimized based on desired sustained release time (12hrs) followed by acceptable swelling and floating properties.

Keywords: Famotidine, Floating tablets, HPMC, Carbopol 934p, Sodium bicarbonate, direct compression, sustained release