PHARMANEST : AN INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACEUTICAL SCIENCES - Volume 4, Issue 6, November - December 2013

Pages: 1698-1710

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FORMULATION AND EVALUATION OF EXTENDED RELEASE TABLETS OF PALIPERIDONE

Author: THIRUMAL KOLA*, Dr.V.UMAMAHESHWARA RAO, CH.S.VIJAYA VANI

Category: Pharmaceutical Sciences

Abstract:

The present research work was an attempt to formulate and Evaluate paliperidone extended release tablets. A combination of Hydroxy propyl methyl cellulose (HPMC K100M) and PVP, poly ethylene oxide were used as polymers. The tablets were prepared by direct compression method 12 formulations were prepared by changing the ratios of the drug and polymer to study the effect of variable concentrations of polymers and characteristics of the tablets. The prepared tablets were evaluated by different parameters such as Thickness, Weight variation, Hardness, Content Uniformity. The tablets were also evaluated for in vitro drug release in 0.1N HCl for 12 h in USP Type II dissolution apparatus. Among all the formulations (F-I to F-XII) prepared, batch F-12 gave relatively slow release of Paliperidone over 24 h when compared to other formulations. The invitro data is fitted in to different kinetic models and the best-fit was achieved with the Korsmeyer-Peppas model. Hence, formulation F12 was found to be equivalent to marketed product with good bioavailability properties. It also showed no significant change in physical appearance, Drug content. The drug carrier interactions were investigated in the solid state by Fourier transform infrared spectroscopic study(FTIR), which was further confirmed by DSC.

Keywords: Paliperidone, HPMC, PVP, Poly ethylene oxide, Evaluation parameters, In-vitro dissolution studies, release kinetics