Pages: 1307-1313
Date of Publication: 01-Dec-2013
HEPATOPROTECTIVE ACTIVITY OF ZIZYPHUS NUMMULARIA (BURM.F.)WIGHT __ampersandsign ARN. AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
Author: RAJASEKARAN S*, R ANANDAN, NISHAD.K.M, VANNAMALAR.S
Category: Pharmaceutical Sciences
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Abstract: Effect of ethanol and aqueous extracts of leaves of Zizyphus nummularia (ZPN) was investigated against carbon tetra chloride-induced hepatic damage. carbon tetra chloride at the rate of 1 ml/kg produced liver damage in rats as manifested by the significant (P< 0.001) rise in serum levels of Serum oxaloacetate transaminase(SGOT), Serum glutamate pyruvate transaminase(SGPT), alkaline phosphatase (ALP), Totalprotein Totalbilirubin and Directbilirubin compared to respective control values. Histopathological observation also revealed that pretreatment with ZPN protected the animals from carbon tetra chloride induced liver damage. The results indicate that the leaves of Zizyphus nummularia possess the Hepatoprotective activity. This property may be attributed to the flavonoids present in the leaves of Zizyphus nummularia.
Keywords: Zizyphus nummularia, carbontetra chloride, hepatotoxins, transaminases, Histopathological studies.
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